English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  In vivo intermolecular zero-quantum coherence MR spectroscopy in the rat spinal cord at 17.6 T: a feasibility study

Balla, D., & Faber, C. (2007). In vivo intermolecular zero-quantum coherence MR spectroscopy in the rat spinal cord at 17.6 T: a feasibility study. Magnetic Resonance Materials in Physics, Biology and Medicine, 20(4), 183-191. doi:10.1007/s10334-007-0081-3.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CB77-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-44DB-9
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Balla, DZ1, 2, Author              
Faber, C, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
2Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              

Content

show
hide
Free keywords: -
 Abstract: Objective: The feasibility of in vivo magnetic resonance spectroscopy of the healthy rat spinal cord at 17.6 T using conventional methods and intermolecular zero-quantum coherence (iZQC) spectroscopy is explored and the performance of both approaches is compared. Methods: Localised spectra were acquired at 17.6 T from three healthy Fisher rats and phantoms with injected iron-oxide particles using the PRESS and a modified HOMOGENIZED sequence. Results: Well-resolved in vivo spectra showing the four singlet resonances of creatine, choline, and N-acetyl aspartate were obtained with both approaches. iZQC spectra were acquired from larger voxels, but did not provide higher sensitivity or resolution in the healthy spinal cord. In the presence of paramagnetic iron-oxide particles, the quality of in vitro spectra acquired with PRESS declined and was strongly dependent on the quality of the local shim. iZQC spectra were not affected by the presence of iron-oxide particles and provided narrow lines (9 Hz) independent of the shim. Conclusion: In vivo iZQC spectroscopy of the rat spinal cord is possible. The robustness in presence of local field distortions makes iZQC methods a promising alternative for the investigation of tissue containing labelled cells, implants, or clotted blood. New application of MRS to tissue inaccessible using conventional methods may thus become possible.

Details

show
hide
Language(s):
 Dates: 2007-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s10334-007-0081-3
BibTex Citekey: 7022
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Amsterdam : No longer published by Elsevier
Pages: - Volume / Issue: 20 (4) Sequence Number: - Start / End Page: 183 - 191 Identifier: ISSN: 0968-5243
CoNE: https://pure.mpg.de/cone/journals/resource/954926245532