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  A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex

Remedios, R., Huilgol, D., Saha, B., Hari, P., Bhatnagar, L., Kowalczyk, T., et al. (2007). A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex. Nature Neuroscience, 10(9), 1141-1150. doi:10.1038/nn1955.

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https://www.nature.com/articles/nn1955.pdf (Publisher version)
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 Creators:
Remedios, R1, Author           
Huilgol , D, Author
Saha, B, Author
Hari, P, Author
Bhatnagar, L, Author
Kowalczyk, T, Author
Hevner, RF, Author
Suda, Y, Author
Aizawa, S, Author
Oshima, T, Author
Stoykova, A, Author
Tole, S, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: The amygdaloid complex consists of diverse nuclei that belong to distinct functional systems, yet many issues about its
development are poorly understood. Here, we identify a stream of migrating cells that form specific amygdaloid nuclei in
mice. In utero electroporation showed that this caudal amygdaloid stream (CAS) originated in a unique domain at the caudal
telencephalic pole that is contiguous with the dorsal pallium, which was previously thought to generate only neocortical cells. The
CAS and the neocortex share mechanisms for specification (transcription factors Tbr1, Lhx2 and Emx1/2) and migration (reelin
and Cdk5). Reelin, a critical cue for migration in the neocortex, and Cdk5, which is specifically required for migration along radial
glia in the neocortex, were both selectively required for the normal migration of the CAS, but not for that of other amygdaloid
nuclei. This is first evidence of a dorsal pallial contribution to the amygdala, demonstrating a developmental and mechanistic link
between the amygdala and the neocortex.

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 Dates: 2007-09
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1038/nn1955
BibTex Citekey: 4666
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Title: Nature Neuroscience
  Other : Nat. Neurosci.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America Inc.
Pages: - Volume / Issue: 10 (9) Sequence Number: - Start / End Page: 1141 - 1150 Identifier: ISSN: 1097-6256
CoNE: https://pure.mpg.de/cone/journals/resource/954925610931