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  Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents

Mishra, A., Fousková, P., Balogh, E., Angelovski, G., Logothetis, N., & Tóth, É. (2007). Synthesis and Relaxation Properties of Three Novel Bis-macrocycles: Attempt towards Calcium Sensitive MRI Contrast Agents. Poster presented at AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CC21-A Version Permalink: http://hdl.handle.net/21.11116/0000-0003-F3F3-8
Genre: Poster

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 Creators:
Mishra, A1, 2, Author              
Fousková, P, Author
Balogh, E, Author
Angelovski, G1, 2, Author              
Logothetis, NK1, 2, Author              
Tóth, É, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: MR contrast agents whose efficiency depends on the concentration of signaling molecules may be used to directly visualize neuronal activation. The so-called ‘smart’ contrast agents for magnetic resonance imaging exhibit dynamic and reversible modulation of their relaxivity by specific physiological or biochemical triggers such as changes in pH, Ca2+ concentration or enzymatic activity. The extracellular concentration of Ca2+ plays an important role in the physiological and pathological processes of the nervous system; it led us to design chelating systems in which the relaxivity is influenced by the Ca2+ concentration. We synthesized three novel bifunctional bismacrocycles based on DO3A-EA coupled to EDTA/DTPA-bisanhydride via amide bonds.

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 Dates: 2007-09
 Publication Status: Published online
 Pages: -
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 Rev. Method: -
 Identifiers: BibTex Citekey: 4698
 Degree: -

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Title: AMI/SMI Joint Molecular Imaging Conference 2007
Place of Event: Providence, RI, USA
Start-/End Date: 2007-09-08 - 2007-09-11

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