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  MR-Based PET Attenuation Correction: Method and Validation

Hofmann, M., Steinke, F., Scheel, V., Charpiat, G., Brady, M., Schölkopf, B., et al. (2007). MR-Based PET Attenuation Correction: Method and Validation. In AMI/SMI Joint Molecular Imaging Conference 2007.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CC29-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-44B6-2
Genre: Meeting Abstract

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Hofmann, M, Author              
Steinke, F1, 2, Author              
Scheel, V, Author
Charpiat, G1, 2, Author              
Brady, M, Author
Schölkopf, B1, 2, Author              
Pichler, BJ, Author
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: PET/MR combines the high soft tissue contrast of Magnetic Resonance Imaging (MRI) and the functional information of Positron Emission Tomography (PET). For quantitative PET information, correction of tissue photon attenuation is mandatory. Usually in conventional PET, the attenuation map is obtained from a transmission scan, which uses a rotating source, or from the CT scan in case of combined PET/CT. In the case of a PET/MR scanner, there is insufficient space for the rotating source and ideally one would want to calculate the attenuation map from the MR image instead. Since MR images provide information about proton density of the different tissue types, it is not trivial to use this data for PET attenuation correction. We present a method for predicting the PET attenuation map from a given the MR image, using a combination of atlas-registration and recognition of local patterns. Using "leave one out cross validation" we show on a database of 16 MR-CT image pairs that our method reliably allows estimating the CT image from the MR image. Subsequently, as in PET/CT, the PET attenuation map can be predicted from the CT image. On an additional dataset of MR/CT/PET triplets we quantitatively validate that our approach allows PET quantification with an error that is smaller than what would be clinically significant. We demonstrate our approach on T1-weighted human brain scans. However, the presented methods are more general and current research focuses on applying the established methods to human whole body PET/MRI applications.

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 Dates: 2007-09
 Publication Status: Published online
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 Identifiers: BibTex Citekey: 4624
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Title: AMI/SMI Joint Molecular Imaging Conference (MIC 2007)
Place of Event: Providence, RI, USA
Start-/End Date: 2007-09-08 - 2007-09-11

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Title: AMI/SMI Joint Molecular Imaging Conference 2007
Source Genre: Proceedings
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