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  High-resolution fMRI of macaque V1

Goense, J., Zappe, A.-C., & Logothetis, N. (2007). High-resolution fMRI of macaque V1. Magnetic Resonance Imaging, 25(6), 740-747.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CC9F-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-E12C-E
Genre: Conference Paper

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 Creators:
Goense, JBM1, 2, Author              
Zappe, A-C1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: To understand the physiological mechanisms underlying the blood-oxygenation-level-dependent (BOLD) signal, the acquisition of data must be optimized to achieve the maximum possible spatial resolution and specificity. The term “specificity” implies the selective enhancement of signals originating in the parenchyma, and thus best reflecting actual neural activity. Such spatial specificity is a prerequisite for imaging aimed at the elucidation of interactions between cortical micromodules, such as columns and laminae. In addition to the optimal selection of functional magnetic resonance imaging pulse sequences, accurate superposition of activation patterns onto corresponding anatomical scans, preferably acquired during the same experimental session, is necessary. At high resolution, exact functional-to-structural registration is of critical importance, because even small differences in geometry, that arise when different sequences are used for functional and anatomical scans, can lead to misallocation of activ ation and erroneous interpretation of data. In the present study, we used spin-echo (SE) echo planar imaging (EPI) for functional scans, since the SE-BOLD signal is sensitive to the capillary response, together with SE-EPI anatomical reference scans. The combination of these acquisition methods revealed a clear spatial colocalization of the largest fractional changes with the Gennari line, suggesting peak activity in Layer IV. Notably, this very same layer coincided with the largest relaxivity changes as observed in steady-state cerebral blood volume measurements, using the intravascular agent monocrystalline iron oxide nanoparticles (MION).

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 Dates: 2007-07
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mri.2007.02.013
BibTex Citekey: 4630
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Title: International School on Magnetic Resonance and Brain Function 2007
Place of Event: Erice, Italy
Start-/End Date: 2007-05-21 - 2007-05-28

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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 25 (6) Sequence Number: - Start / End Page: 740 - 747 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026