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  Metabolic Characterization of Patients with Alcohol and Non-Alcoholic Steatohepatitis

Gottschalk, S., Hohnholt, M., Bilodeau, M., Leibfritz, D., & Zwingmann, C. (2007). Metabolic Characterization of Patients with Alcohol and Non-Alcoholic Steatohepatitis. Poster presented at 2007 Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany.

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Gottschalk, S1, Author              
Hohnholt , M, Author
Bilodeau, M, Author
Leibfritz, D, Author
Zwingmann, C, Author
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1External Organizations, ou_persistent22              

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 Abstract: Liver steatosis is an increasingly common cause of liver diseases. Today it is still difficult to differentiate patients with non-alcoholic steatohepatitis (NASH) from patients with alcoholic steatohepatitis (ASH) on the basis of clinical and biochemical evaluations. Since it is becoming urgent to develop new diagnostic methods for NASH, we applied high-resolution 1H- and (natural abundance) 13C-NMR spectroscopy to detect metabolic profiles in preparations of blood and urine in patients with NASH and ASH. 1H- and 13C-NMR spectra of urine and blood samples showed considerable and reproducible differences in specific metabolites involved in intermediary as well as lipid metabolism in patients with NASH and ASH compared to healthy controls. The results demonstrate that NMR applications on human body fluids are of great potential to characterize NASH, a disease displaying multiple interrelated metabolic factors. This approach could provide noninvasively data to characterize steatosis and give the possibility to distinguish between NASH and ASH.

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 Dates: 2007-05
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: GottschalkHBLZ2007
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Title: 2007 Joint Annual Meeting ISMRM-ESMRMB
Place of Event: Berlin, Germany
Start-/End Date: 2007-05-19 - 2007-05-25

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Title: 2007 Joint Annual Meeting ISMRM-ESMRMB
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2753 Start / End Page: 533 Identifier: -