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  MR Contrast Agent Coupled to an Antisense Peptide Nucleic Acid - Cell Penetrating Peptide Conjugate

Engelmann, J., Su, W., Mishra, R., Pfeuffer, J., Wiesmüller, K., & Ugurbil, K. (2007). MR Contrast Agent Coupled to an Antisense Peptide Nucleic Acid - Cell Penetrating Peptide Conjugate. Poster presented at 2007 Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany.

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Externe Referenzen

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externe Referenz:
https://cds.ismrm.org/ismrm-2007/files/1_program.pdf (Zusammenfassung)
Beschreibung:
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Urheber

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 Urheber:
Engelmann, J1, 2, Autor           
Su, W1, 2, Autor           
Mishra, R1, 2, Autor           
Pfeuffer, J, Autor           
Wiesmüller, KH, Autor
Ugurbil, K, Autor
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Inhalt

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Schlagwörter: -
 Zusammenfassung: An antisense MR contrast agent and its nonsense counterpart, conjugated to a peptide nucleic acid and a cell penetrating peptide were synthesized capable of
targeting cellular mRNA. Intracellular uptake in non-targeted 3T3 fibroblasts was confirmed by fluorescence and MR studies. The intracellular relaxation rate R1,cell increased significantly already at a labeling concentration of 0.5 μM, thus contrast enhancement was also detectable. An in vitro binding assay provided first evidence of a higher specificity of the antisense contrast agent. These results demonstrate its potential to be used as a targeted contrast agent for tracking mRNA transcription in cells by MRI.

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Sprache(n):
 Datum: 2007-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: BibTex Citekey: 5141
 Art des Abschluß: -

Veranstaltung

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Titel: 2007 Joint Annual Meeting ISMRM-ESMRMB
Veranstaltungsort: Berlin, Germany
Start-/Enddatum: 2007-05-19 - 2007-05-25

Entscheidung

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Projektinformation

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Quelle 1

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Titel: 2007 Joint Annual Meeting ISMRM-ESMRMB
Genre der Quelle: Konferenzband
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: - Artikelnummer: 1161 Start- / Endseite: 251 Identifikator: -