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Abstract:
The spatio-temporal noise properties fundamentally influence the functional result in fMRI. Although the significant gains of three-dimensional acquisition
with parallel imaging to fMRI has been shown, the effects of their application on noise and signal properties have so far not been quantitatively considered. This study investigated these aspects by comparing results from conventional 2D multi-slice, 3D-EPI full scan and 3D-EPI with 1-dimensional reduction factors of 2 and 4. Results showed significant signal changes with high acceleration. 3D methods showed comparable signal stability levels to 2D, but yielded overall higher spatio-temporal signal correlations.
