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  Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 Tesla

Shmuel, A., Yacoub, E., Chaimow, D., Logothetis, N., & Ugurbil, K. (2007). Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 Tesla. NeuroImage, 35(2), 539-552. doi:10.1016/j.neuroimage.2006.12.030.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CE03-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4268-D
Genre: Journal Article

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Shmuel, A1, 2, Author              
Yacoub, E, Author
Chaimow, D2, 3, Author              
Logothetis, NK1, 2, Author              
Ugurbil, K, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              

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 Abstract: This study investigated the spatio-temporal properties of blood-oxygenation level-dependent (BOLD) functional MRI (fMRI) signals in gray matter, excluding the confounding, inaccurate contributions of large blood vessels. We quantified the spatial specificity of the BOLD response, and we investigated whether this specificity varies as a function of time from stimulus onset. fMRI was performed at 7 Tesla (T), where mapping signals of parenchymal origin are easily detected. Two abutting visual stimuli were adjusted to elicit responses centered on a flat gray matter region in V1. fMRI signals were sampled at high-resolution orthogonal to the retinotopic boundary between the representations of the stimuli. Signals from macro-vessels were masked out. Principal component analysis revealed that the first component in space accounted for 96.2 ± 1.6% of the variance over time. The spatial profile of this time-invariant response was fitted with a model consisting of the convolution of a step function and a Gaussian point-spread-function (PSF). The mean full-width at half-maximal-height of the fitted PSF was 2.34 ± 0.20 mm. Based on simulations of confounding effects, we estimate that BOLD PSF in human gray matter is smaller than 2 mm. A time-point to time-point analysis revealed that the PSF obtained during the 3rd (1.52 mm) and 4th (1.99 mm) seconds of stimulation were narrower than the mean PSF obtained from the 5th second on (2.42 ± 0.15 mm). The position of the edge of the responding region was offset (1.72 ± 0.07 mm) from the boundary of the stimulated region, indicating a spatial non-linearity. Simulations showed that the effective contrast between active and non-active columns is reduced 25-fold when imaged using a PSF whose width is equal to the cycle of the imaged columnar organization.

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 Dates: 2007-04
 Publication Status: Published in print
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 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2006.12.030
BibTex Citekey: 4292
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 35 (2) Sequence Number: - Start / End Page: 539 - 552 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166