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  A steady-state model of spreading depression predicts the importance of an unknown conductance in specific dendritic domains

Makarowa, J., Ibarz, J., Canals, S., & Herreras, O. (2007). A steady-state model of spreading depression predicts the importance of an unknown conductance in specific dendritic domains. Biophysical Journal, 92(12), 4216-4232. doi:10.1529/biophysj.106.090332.

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Makarowa, J, Author
Ibarz, JM, Author
Canals, S1, 2, Author              
Herreras, O, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Spreading depression (SD) is a pathological wave of transient neuronal inactivation. We recently reported that the characteristic sustained complete depolarization is restricted to specific cell domains where the input resistance (Rin) first becomes negligible before achieving partial recovery, whereas in adjacent, more polarized membranes it drops by much less. The experimental study of the participating membrane channels is hindered by their mixed contribution and heterogeneous distribution. Therefore, we derived a biophysical model to analyze the conductances that replicate the subcellular profile of Rin during SD. Systematic variation of conductance densities far beyond the ranges reported failed to fit the experimental values. Besides standard potassium, sodium, and Glu-mediated conductances, the initial opening and gradual closing of an as yet undetermined large conductance is required to account for the evolution of Rin. Potassium conductances follow in the relative contribution and their closing during the late phase is also predicted. Large intracellular potential gradients from zero to rest are readily sustained between shunted and adjacent SD-spared membranes, which remain electroregenerative. The gradients are achieved by a combination of high-conductance subcellular domains and transmembrane ion redistribution in extended but discrete dendritic domains. We conclude that the heterogeneous subcellular behavior is due to local membrane properties, some of which may be specifically activated under extreme SD conditions.

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 Dates: 2007-03
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1529/biophysj.106.090332
BibTex Citekey: 4303
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Title: Biophysical Journal
  Other : Biophys. J.
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 92 (12) Sequence Number: - Start / End Page: 4216 - 4232 Identifier: ISSN: 0006-3495
CoNE: https://pure.mpg.de/cone/journals/resource/954925385117