English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice

Szinyei, C., Narayanan, R., & Pape, H. (2007). Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice. European Journal of Neuroscience: European Neuroscience Association, 25(4), 1205-1211. doi:10.1111/j.1460-9568.2007.05349.x.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Szinyei, C, Author
Narayanan, RT1, Author              
Pape, HC, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: After fear conditioning, plastic changes of excitatory synaptic transmission occur in the amygdala. Fear-related memory also involves the GABAergic system, although no influence on inhibitory synaptic transmission is known. In the present study we assessed the influence of Pavlovian fear conditioning on the plasticity of GABAergic synaptic interactions in the lateral amygdala (LA) in brain slices prepared from fear-conditioned, pseudo-trained and naïve adult mice. Theta-burst tetanization of thalamic afferent inputs to the LA evoked an input-specific potentiation of inhibitory postsynaptic responses in projection neurons; the cortical input was unaffected. Philanthotoxin (10 µm), an antagonist of Ca2+-permeable AMPA receptors, disabled this plastic phenomenon. Surgical isolation of the LA, extracellular application of a GABAB receptor antagonist (CGP 55845A, 10 µm) or an NMDA receptor antagonist (APV, 50 µm), or intracellular application of BAPTA (10 mm), did not influence the plasticity. The plasticity also showed as a potentiation of monosynaptic excitatory responses in putative GABAergic interneurons. Pavlovian fear conditioning, but not pseudo-conditioning, resulted in a significant reduction in this potentiation that was evident 24 h after training. Two weeks after training, the potentiation returned to control levels. In conclusion, a reduction in potentiation of inhibitory synaptic interactions occurs in the LA and may contribute to a shift in synaptic balance towards excitatory signal flow during the processes of fear-memory acquisition or consolidation.

Details

show
hide
Language(s):
 Dates: 2007-02
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/j.1460-9568.2007.05349.x
BibTex Citekey: SzinyeiNP2007
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: European Journal of Neuroscience : European Neuroscience Association
  Other : Eur. J. Neurosci
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 25 (4) Sequence Number: - Start / End Page: 1205 - 1211 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988