English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity

Power, A., Wang, J., Falls, T., Paterson, J., Parato, K., Lichty, B., et al. (2007). Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity. Molecular Therapy, 15(1), 123-130. doi:10.1038/sj.mt.6300039.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CEE5-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D0BA-0
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Power, AT1, Author              
Wang , J, Author
Falls, TJ, Author
Paterson, JM, Author
Parato, KA, Author
Lichty, BD, Author
Stojdl, DF, Author
Forsyth, PA, Author
Atkins, H, Author
Bell, JC, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Oncolytic viruses capable of tumor-selective replication and cytolysis have shown early promise as cancer therapeutics. However, the host immune system remains a significant obstacle to effective systemic administration of virus in a clinical setting. Here, we demonstrate the severe negative impact of the adaptive immune response on the systemic delivery of oncolytic vesicular stomatitis virus (VSV) in an immune-competent murine tumor model, an effect mediated primarily by the neutralization of injected virions by circulating antibodies. We show that this obstacle can be overcome by administering virus within carrier cells that conceal viral antigen during delivery. Infected cells were delivered to tumor beds and released virus to infect malignant cells while sparing normal tissues. Repeated administration of VSV in carrier cells to animals bearing metastatic tumors greatly improved therapeutic efficacy when compared with naked virion injection. Whole-body molecular imaging revealed that carrier cells derived from solid tumors accumulate primarily in the lungs following intravenous injection, whereas leukemic carriers disseminate extensively throughout the body. Furthermore, xenogeneic cells were equally effective at delivering virus as syngeneic cells. These findings emphasize the importance of establishing cell-based delivery platforms in order to maximize the efficacy of oncolytic therapeutics.

Details

show
hide
Language(s):
 Dates: 2007-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/sj.mt.6300039
BibTex Citekey: PowerWFPPLSFAB2007
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Therapy
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Diego, CA : No longer published by Elsevier
Pages: - Volume / Issue: 15 (1) Sequence Number: - Start / End Page: 123 - 130 Identifier: ISSN: 1525-0016
CoNE: https://pure.mpg.de/cone/journals/resource/961066780010