Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization

Smirnakis, S., Schmid, M., Weber, B., Tolias, A., Augath, M., & Logothetis, N. (2007). Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization. Journal of Cerebral Blood Flow and Metabolism, 27(6), 1248-1261. doi:10.1038/sj.jcbfm.9600434.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Smirnakis, SM1, 2, Autor           
Schmid, MC1, 2, Autor           
Weber, B1, 2, Autor           
Tolias, AS1, 2, Autor           
Augath, M1, 2, Autor           
Logothetis, NK1, 2, Autor           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Intravascular contrast agents are used in functional magnetic resonance imaging to obtain cerebral blood volume (CBV) maps of cortical activity. Cerebral blood volume imaging with MION (monocrystalline-iron-oxide-nanoparticles) increases the sensitivity of functional imaging compared with the blood oxygenation level-dependent (BOLD) signal (Leite et al, 2002; Mandeville et al, 1998; Vanduffel et al, 2001). It therefore represents an attractive method for obtaining detailed maps of cortical organization (Vanduffel et al, 2001; Zhao et al, 2005). However, it remains to be determined how the spatial profile of CBV maps of cortical activity derived with MION compares with the profile of BOLD activation maps under a variety of different stimulation conditions. We used several stimulation paradigms to compare the spatial specificity of CBV versus BOLD activation maps in macaque area V1 at 4.7 T. We observed that: (1) CBV modulation is relatively stronger in deep cortical layers compared with BOLD, in agreement with
studies in cats (Harel et al, 2006) and rodents (Lu et al, 2004; Mandeville and Marota, 1999) and (2) surprisingly, under large surround stimulation conditions, CBV maps extend along the cortical surface to cover large (amp;gt;10 mm) regions of the cortex that are devoid of significant BOLD modulation. We conclude that the spatial profiles of BOLD and CBV activity maps do not coregister across all stimulus conditions, and therefore do not necessarily represent equivalent transforms of the neural response. Cerebral blood volume maps should be interpreted with care, in the context of the particular experimental paradigm applied.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2007-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1038/sj.jcbfm.9600434
BibTex Citekey: 3827
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Cerebral Blood Flow and Metabolism
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: New York : Lippincott Williams & Wilkins
Seiten: - Band / Heft: 27 (6) Artikelnummer: - Start- / Endseite: 1248 - 1261 Identifikator: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202