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  Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization

Smirnakis, S., Schmid, M., Weber, B., Tolias, A., Augath, M., & Logothetis, N. (2007). Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization. Journal of Cerebral Blood Flow and Metabolism, 27(6), 1248-1261. doi:10.1038/sj.jcbfm.9600434.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CEF1-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-D104-C
Genre: Journal Article

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Smirnakis, SM1, 2, Author              
Schmid, MC1, 2, Author              
Weber, B1, 2, Author              
Tolias, AS1, 2, Author              
Augath, M1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Intravascular contrast agents are used in functional magnetic resonance imaging to obtain cerebral blood volume (CBV) maps of cortical activity. Cerebral blood volume imaging with MION (monocrystalline-iron-oxide-nanoparticles) increases the sensitivity of functional imaging compared with the blood oxygenation level-dependent (BOLD) signal (Leite et al, 2002; Mandeville et al, 1998; Vanduffel et al, 2001). It therefore represents an attractive method for obtaining detailed maps of cortical organization (Vanduffel et al, 2001; Zhao et al, 2005). However, it remains to be determined how the spatial profile of CBV maps of cortical activity derived with MION compares with the profile of BOLD activation maps under a variety of different stimulation conditions. We used several stimulation paradigms to compare the spatial specificity of CBV versus BOLD activation maps in macaque area V1 at 4.7 T. We observed that: (1) CBV modulation is relatively stronger in deep cortical layers compared with BOLD, in agreement with studies in cats (Harel et al, 2006) and rodents (Lu et al, 2004; Mandeville and Marota, 1999) and (2) surprisingly, under large surround stimulation conditions, CBV maps extend along the cortical surface to cover large (amp;gt;10 mm) regions of the cortex that are devoid of significant BOLD modulation. We conclude that the spatial profiles of BOLD and CBV activity maps do not coregister across all stimulus conditions, and therefore do not necessarily represent equivalent transforms of the neural response. Cerebral blood volume maps should be interpreted with care, in the context of the particular experimental paradigm applied.

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 Dates: 2007-01
 Publication Status: Published in print
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 Identifiers: DOI: 10.1038/sj.jcbfm.9600434
BibTex Citekey: 3827
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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 27 (6) Sequence Number: - Start / End Page: 1248 - 1261 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202