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  Global Biclustering of Microarray Data

Wolf, T., Brors, B., Hofmann, T., & Georgii, E. (2006). Global Biclustering of Microarray Data. In S. Tsumoto, C. Clifton, N. Zhong, X. Wu, J. Liu, B. Wah, et al. (Eds.), Sixth IEEE International Conference on Data Mining - Workshops (ICDMW'06) (pp. 125-129). Los Alamitos, CA, USA: IEEE Computer Society.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CF49-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9686-B
Genre: Conference Paper

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 Creators:
Wolf, T, Author
Brors, B, Author
Hofmann, T1, Author              
Georgii, E1, Author              
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: We consider the problem of simultaneously clustering genes and conditions of a gene expression data matrix. A bicluster is defined as a subset of genes that show similar behavior within a subset of conditions. Finding biclusters can be useful for revealing groups of genes involved in the same molecular process as well as groups of conditions where this process takes place. Previous work either deals with local, bicluster-based criteria or assumes a very specific structure of the data matrix (e.g. checkerboard or block-diagonal) [11]. In contrast, our goal is to find a set of flexibly arranged biclusters which is optimal in regard to a global objective function. As this is a NP-hard combinatorial problem, we describe several techniques to obtain approximate solutions. We benchmarked our approach successfully on the Alizadeh B-cell lymphoma data set [1].

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 Dates: 2006-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1109/ICDMW.2006.88
BibTex Citekey: 4381
 Degree: -

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Title: Sixth IEEE International Conference on Data Mining Workshops (ICDMW 2006)
Place of Event: Hong Kong, China
Start-/End Date: 2006-12-18 - 2006-12-22

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Title: Sixth IEEE International Conference on Data Mining - Workshops (ICDMW'06)
Source Genre: Proceedings
 Creator(s):
Tsumoto, S, Editor
Clifton, CW, Editor
Zhong, N, Editor
Wu, X, Editor
Liu, J, Editor
Wah, BW, Editor
Cheung, Y-M, Editor
Affiliations:
-
Publ. Info: Los Alamitos, CA, USA : IEEE Computer Society
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 125 - 129 Identifier: ISBN: 0-7695-2792-2