English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Large-Scale Gene Expression Profiling Reveals Major Pathogenetic Pathways of Cartilage Degeneration in Osteoarthritis

Aigner, T., Fundel, K., Saas, J., Gebhard, P., Haag, J., Weiss, T., et al. (2006). Large-Scale Gene Expression Profiling Reveals Major Pathogenetic Pathways of Cartilage Degeneration in Osteoarthritis. Arthritis and Rheumatism, 54(11), 3533-3544. doi:10.1002/art.22174.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CFBD-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-4C80-6
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Aigner, T, Author
Fundel, K, Author
Saas, J, Author
Gebhard, PM, Author
Haag, J, Author
Weiss , T, Author
Zien, A1, 2, Author              
Obermayr, F, Author
Zimmer, R, Author
Bartnik, E, Author
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: Objective. Despite many research efforts in recent decades, the major pathogenetic mechanisms of osteo-arthritis (OA), including gene alterations occurring during OA cartilage degeneration, are poorly under- stood, and there is no disease-modifying treatment approach. The present study was therefore initiated in order to identify differentially expressed disease-related genes and potential therapeutic targets. Methods. This investigation consisted of a large gene expression profiling study performed based on 78 normal and disease samples, using a custom-made complementar y DNA array covering gt;4,000 genes. Results. Many differentially expressed genes were identified, including the expected up-regulation of ana- bolic and catabolic matrix genes. In particular, the down-regulation of important oxidative defense genes, i.e., the genes for superoxide dismutases 2 and 3 and glutathione peroxidase 3, was prominent. This indicates that continuous oxidative stress to the cells and the matrix is one major underlying pathogenetic mecha- nism in OA. Also, genes that are involved in the phenot ypic stabilit y of cells, a feature that is greatly reduced in OA cartilage, appeared to be suppressed. Conclusion. Our findings provide a reference data set on gene alterations in OA cartilage and, importantly, indicate major mechanisms underlying central cell bio- logic alterations that occur during the OA disease process. These results identify molecular targets that can be further investigated in the search for therapeutic interventions.

Details

show
hide
Language(s):
 Dates: 2006-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/art.22174
BibTex Citekey: 3852
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Arthritis and Rheumatism
  Other : Arthritis Rheum.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : John Wiley & Sons
Pages: - Volume / Issue: 54 (11) Sequence Number: - Start / End Page: 3533 - 3544 Identifier: ISSN: 0004-3591
CoNE: https://pure.mpg.de/cone/journals/resource/954925382045