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  Spatially localized intermolecular zero-quantum coherence spectroscopy for in vivo applications

Balla, D., Melkus, G., & Faber, C. (2006). Spatially localized intermolecular zero-quantum coherence spectroscopy for in vivo applications. Magnetic Resonance in Medicine, 56(4), 745-753. doi:10.1002/mrm.21007.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-CFCB-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-6FBE-B
Genre: Journal Article

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Balla, DZ1, Author              
Melkus, G, Author
Faber, C, Author
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1External Organizations, ou_persistent22              

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 Abstract: Magnetic resonance spectroscopy (MRS) techniques that use the distant dipolar field (DDF) to locally refocus inhomogeneous line-broadening promise improved spectral resolution in spatially varying fields. We investigated three possible implementations of localized DDF spectroscopy. Theoretical analysis and phantom experiments at 17.6 T showed that only localization immediately prior to acquisition provides sufficient spatial selectivity and sensitivity for in vivo applications. Spectra from an (8 mm)3 voxel of the rat brain were acquired in 25 min, and three major metabolites were resolved. In a tumor mouse model, DDF spectra with well-resolved lines can be obtained from significantly larger voxels compared to conventional localized spectroscopy. From an inhomogeneous voxel, improved spectral resolution can be obtained with DDF techniques when a sufficient number of increments are sampled along the second spectral dimension. With fewer increments, measurement time is significantly shortened, and DDF techniques can provide higher signal-to-noise ratio (SNR) efficiency.

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 Dates: 2006-10
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/mrm.21007
BibTex Citekey: 7020
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 56 (4) Sequence Number: - Start / End Page: 745 - 753 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149