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  Combining MRI with invasive neuroscientific techniques: An attempt to study distributed neural networks

Logothetis, N. (2006). Combining MRI with invasive neuroscientific techniques: An attempt to study distributed neural networks. Talk presented at 23rd Annual Scientific Meeting of the ESMRMB 2006. Warsaw, Poland. 2006-09-21 - 2006-09-23.

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 Creators:
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The combination of fMRI with electrophysiology, histology, and neurochemistry promises great insights into a level of neural organization that could have never been studied with either technique alone. My talk will focus on (a) spatially resolved fMRI and MRSI (spectroscopic imaging); (b) the study of in vivo connectivity using fMRI and electrical microstimulation, or manganese-enhanced MRI; (c) combined physiology and MRI for examining the electrical activity occurring during increases and decreases of BOLD activation, and (d) molecular imaging based on smart agents. MRSI optimization enabled sufficiently high spectral dispersion and spatiotemporal resolution to obtain isolated glutamate maps in the primate brain. Ongoing research attempts the differentiation of brain structures in the millimeter range and/or detection of small concentration differences in the same structure (activated vs. non-activated cortex). Finally, I will report our first attempt (a) to develop chelates for Gd and endow them with the appropriate coordinating groups that reversibly block some of the Gd’s free coordination sites with changes in pH or [Ca++].

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 Dates: 2006-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s10334-006-0040-4
BibTex Citekey: 5850
 Degree: -

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Title: 23rd Annual Scientific Meeting of the ESMRMB 2006
Place of Event: Warsaw, Poland
Start-/End Date: 2006-09-21 - 2006-09-23
Invited: Yes

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Title: Magnetic Resonance Materials in Physics, Biology and Medicine
Source Genre: Journal
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Publ. Info: Amsterdam : No longer published by Elsevier
Pages: - Volume / Issue: 19 (Supplement 1) Sequence Number: 10 Start / End Page: 8 Identifier: ISSN: 0968-5243
CoNE: https://pure.mpg.de/cone/journals/resource/954926245532