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  Accelerated 3D-EPI fMRI Using Parallel Imaging

Nguyen, T., Moeller, S., Goerke, U., & Ugurbil, K. (2006). Accelerated 3D-EPI fMRI Using Parallel Imaging. Poster presented at 23rd Annual Scientific Meeting of the ESMRMB 2006, Warsaw, Poland.

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 Urheber:
Nguyen, T1, 2, Autor           
Moeller , S, Autor
Goerke, U, Autor
Ugurbil, K, Autor
Affiliations:
1Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Zusammenfassung: Introduction: Fast, three-dimensional acquisition is advantageous for
fMRI1. While advanced 3D methods have been demonstrated for fMRI, 2Dmulti-
slice EPI remains the convention. Extension to 3D-EPI using phaseencoding
in the slice selection direction has presented feasible results2, but to
our knowledge so far only within the conventional EPI temporal framework.
Parallel imaging (PI) can provide a desirable improvement in both temporal
resolution and CNR. This work seeks to evaluate some features of employing
accelerated 3D-EPI for fMRI compared to conventional method.
Methods: Data acquisition: 3T Siemens scanner, 8-channel head coil,
segmented EPI sequence. Studies were performed on a healthy volunteer
using four EPI schemes: conventional 2D-multi-slice, 3D full volume scan,
3D scans accelerated in 1-dimension with reduction factors R=2 and R=4.
All acquisition parameters were identical except for variations inherent to
the 2D sequence. Volumes of 20 slices were attained in ~7 s in 2D-multislice
and down to ~2 s in 3D with R=4. Reconstruction was offline using
GRAPPA.
Functional imaging: motor task paradigm with self-paced, right-handed
finger tapping ~30s off / 30s on blocks. Time series with 90 repetitions were
acquired and activation maps (t-scores) were generated with variations in
thresholds accounting for differences in intrinsic CNR and SNR (fig. 2).
Results: Results show overall similar activation structure in the contralateral
primary motor cortex and the supplementary motor area (fig. 1). Activation
was detected consistently with all acquisition schemes (fig. 2), even with
high 1-dimensional undersampling. The activation maps for R=4 showed
a smaller reduction in t-scores (~30 ) compared to the reduction in SNR
(75). Further, acceleration reduced total scan time up to a factor of 3.5
relative to the full k-space acquisitions.
Conclusion: Acceleration offers significant gains to 3D-EPI for fMRI.
Although loss of spatial SNR with shortened acquisition time is expected
to reduce t-scores, acceleration is feasible due to the increase in acquired
volumes per time and relatively disproportional smaller loss of CNR. Limits
to acceleration are indicated in the activation maps as further reduction will
give proportionally decreased CNR. However, high 1-dimensional reduction
factors were shown to be feasible, achieving both spatial specificity of the
functional response and higher temporal resolution than obtainable with 2Dmulti-
slice within equal scan durations and spatial coverage. Additionally, a
3D scheme offers the possibility of two-dimensional acceleration for further
imaging flexibility.

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 Datum: 2006-09
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1007/s10334-006-0043-1
BibTex Citekey: 5553
 Art des Abschluß: -

Veranstaltung

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Titel: 23rd Annual Scientific Meeting of the ESMRMB 2006
Veranstaltungsort: Warsaw, Poland
Start-/Enddatum: 2006-09-21 - 2006-09-23

Entscheidung

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Quelle 1

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Titel: Magnetic Resonance Materials in Physics, Biology and Medicine
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: Amsterdam : No longer published by Elsevier
Seiten: - Band / Heft: 19 (Supplement 1) Artikelnummer: 622 Start- / Endseite: 306 - 307 Identifikator: ISSN: 0968-5243
CoNE: https://pure.mpg.de/cone/journals/resource/954926245532