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  FMRI of V1 microarchitecture in the macaque at 4.7T

Goense, J., & Logothetis, N. (2006). FMRI of V1 microarchitecture in the macaque at 4.7T. Poster presented at AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles, Santorini, Greece.

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https://areadne.org/2006/ (Zusammenfassung)
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Urheber

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 Urheber:
Goense, JBM1, 2, Autor           
Logothetis, NK1, 2, Autor           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Zusammenfassung: For fMRI to be able to provide insight in the cortical circuitry, the spatial resolution and specificity of the fMRI signal need to be sufficient to visualize the microarchitecture of the cortex at the laminar and
columnar level. The current spatial resolution of the fMRI signal however is too coarse to be able to
reliably visualize the cortical microarchitecture. Cortical columns of ~1 mm have been observed with
fMRI, but achieving higher (submillimeter) resolution is problematic, because the specificity of the
activation is determined by the hemodynamic properties of the vascular bed. The conventional Gradient-
Echo (GE) sequence used for BOLD-fMRI is sensitive to signal from veins and venules, and is strongest
at the cortical surface, where draining vessels are located. This has limited the spatial specificity of the
conventional fMRI signal to about 1 mm. By using the Spin-Echo (SE) fMRI signal instead, which is more
sensitive to the capillary fraction, and less sensitive to veins, the specificity of the fMRI signal can be
enhanced. Sequence optimization allowed us to further increase spatial specificity, and to achieve
submillimeter spatial resolution. This resolution allows visualization of the cortical laminae, as shown in
V1 in the anesthetized macaque (figure). The SE-BOLD signal was localized to layer IV/Duvernoy layer 3,
with little activation in the upper cortical layers. The spatial resolution and specificity shown here allows
determination of differences in laminar profiles depending on visual input. When motion and flicker stimuli
were compared, the unequal laminar distribution of motion-direction selective laminae could be clearly
discerned. Our results indicate that the point spread function for SE-fMRI is 0.5 mm or less, and is
sufficient to observe differences in functional activation at laminar resolution.

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 Datum: 2006-06
 Publikationsstatus: Erschienen
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 Identifikatoren: BibTex Citekey: 4287
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Veranstaltung

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Titel: AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles
Veranstaltungsort: Santorini, Greece
Start-/Enddatum: 2006-06-22 - 2006-06-25

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Quelle 1

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Titel: AREADNE 2006: Research in Encoding and Decoding of Neural Ensembles
Genre der Quelle: Konferenzband
 Urheber:
Pezaris, JS, Herausgeber
Hatsopoulos, NG, Herausgeber
Affiliations:
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Ort, Verlag, Ausgabe: Cambridge, MA, USA : AREADNE Foundation
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 50 Identifikator: -