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  Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study

Engelmann, J., Su, W., Jha, D., Mishra, R., Pfeuffer, J., & Ugurbil, K. (2006). Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study. Poster presented at 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D201-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-C713-6
Genre: Poster

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ISMRM-2006-Engelmann.pdf (Any fulltext), 515KB
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 Creators:
Engelmann, J1, 2, Author              
Su, W1, 2, Author              
Jha, D1, 2, Author              
Mishra, R1, 2, Author              
Pfeuffer, J1, 3, Author              
Ugurbil, K, Author
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
2Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              
3Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: For the development of intracellular Magnetic Resonance contrast agents (CAs) it is a prerequisite that they cross the plasma membrane. Cell penetrating peptides (CPPs) are known to transport cargo molecules attached to it into cells. We synthesized intracellular CAs containing known CPPs or modified peptides. Gd-diethylenetriaminepenta-acetic acid (Gd-DTPA) was coupled to CPPs for MR visualization and fluorescence imaging agent fluorescein isothiocyanate (FITC) for tracking the agent inside cells by optical imaging. Compared on the basis of these measurements, modifications in CPPs enhanced the intracellular delivery ability of our CAs providing a tool for stable labeling of cells for MR imaging.

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 Dates: 2006-05
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 5140
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Title: 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006)
Place of Event: Seattle, WA, USA
Start-/End Date: 2006-05-06 - 2006-05-12

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Title: 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 1887 Start / End Page: 374 Identifier: -