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  Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography

Zhang, C., Zhang, X., Zhang, Y., Xu, Q., Xiao, H., & Liang, X. (2006). Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography. Journal of Ethnopharmacology, 105(1-2), 223-228. doi:10.1016/j.jep.2005.10.029.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D21B-D Version Permalink: http://hdl.handle.net/21.11116/0000-0004-867B-B
Genre: Journal Article

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Zhang, C, Author
Zhang, X1, Author              
Zhang , Y, Author
Xu, Q, Author
Xiao, H, Author
Liang, X, Author
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1External Organizations, ou_persistent22              

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 Abstract: The estrogenic activity of traditional Chinese herb-Polygonum cuspidatum Sieb. et Zucc. was investigated by a recombinant yeast screening (YES) assay. Anthraquinones are the main components in the plant, of which emodin is the most abundant one. The ethyl acetate fraction of the ethanol extract of Polygonum cuspidatum was separated on a silica gel TLC plate and seven sub-fractions were collected. The results of bioassay demonstrated that Hzs1 and Hzs6 showed higher estrogenic activities than that of others and the potency of these two compounds were approximately 10(-4) g/L and 10(-3) g/L, respectively. HPLC analysis was performed to determine the activities and the active components. Combining the results of HPLC analysis and estrogenic activity test by YES led to the conclusion that an unknown bioactive compound might exist in the extraction of Polygonum cuspidatum.

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 Dates: 2006-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.jep.2005.10.029
BibTex Citekey: 4450
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Title: Journal of Ethnopharmacology
Source Genre: Journal
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Publ. Info: New York, NY [u.a.] : Elsevier
Pages: - Volume / Issue: 105 (1-2) Sequence Number: - Start / End Page: 223 - 228 Identifier: ISSN: 0378-8741
ISSN: 1872-7573
CoNE: https://pure.mpg.de/cone/journals/resource/0378-8741