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  Direct and Indirect Activation of Cortical Neurons by Electrical Microstimulation

Tehovnik, E., Tolias, A., Sultan, F., Slocum, W., & Logothetis, N. (2006). Direct and Indirect Activation of Cortical Neurons by Electrical Microstimulation. Journal of Neurophysiology, 96(2), 512-521. doi:10.1152/jn.00126.2006.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D21D-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-8B47-E
Genre: Journal Article

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Tehovnik, EJ, Author
Tolias, AS1, 2, Author              
Sultan, F, Author              
Slocum, WM, Author
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Electrical microstimulation has been used to elucidate cortical function. This review discusses neuronal excitability and effective current spread estimated by using three different methods: 1) single-cell recording, 2) behavioral methods, and 3) functional magnetic resonance imaging (fMRI). The excitability properties of the stimulated elements in neocortex obtained using these methods were found to be comparable. These properties suggested that microstimulation activates the most excitable elements in cortex, that is, by and large the fibers of the pyramidal cells. Effective current spread within neocortex was found to be greater when measured with fMRI compared with measures based on single-cell recording or behavioral methods. The spread of activity based on behavioral methods is in close agreement with the spread based on the direct activation of neurons (as opposed to those activated synaptically). We argue that the greater activation with imaging is attributed to transynaptic spread, which includes sub threshold activation of sites connected to the site of stimulation. The definition of effective current spread therefore depends on the neural event being measured.

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 Dates: 2006-04
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1152/jn.00126.2006
BibTex Citekey: 4379
 Degree: -

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Title: Journal of Neurophysiology
  Other : J. Neurophysiol.
Source Genre: Journal
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Publ. Info: Bethesda, MD : The Society
Pages: - Volume / Issue: 96 (2) Sequence Number: - Start / End Page: 512 - 521 Identifier: ISSN: 0022-3077
CoNE: https://pure.mpg.de/cone/journals/resource/954925416959