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  Determination of tiopronin in human plasma by HPLC-MS with precolumn derivatization.

Li, J., Bi, S., & Chen, H. (2006). Determination of tiopronin in human plasma by HPLC-MS with precolumn derivatization. Chinese Journal of New Drugs and Clinical Remedies, 25(6), 421-423.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D305-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-9654-4
Genre: Journal Article

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Li, J1, Author              
Bi, SK, Author
Chen, HX, Author
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1External Organizations, ou_persistent22              

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 Abstract: Tiopronin (2-mercaptopropionylglycine, TP) is a thiol compound, which has been used as a hepatoprotective and anti-cataract agent. It also modifies rheumatoid arthritis and has been applied in the treatment of cystinuria. In this study, a sensitive and reproducible HPLC-MS method has been developed for the analysis of tiopronin in human plasma. Pre-column derivatization with 2, 4-dinitrofluorobenzene (DNCB), the blood plasma was de-proteinized and purified by liquid-liquid extraction. This assay method was successively applied to a pharmacokinetics study.

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 Dates: 2006-01
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 6176
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Title: Chinese Journal of New Drugs and Clinical Remedies
Source Genre: Journal
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Pages: - Volume / Issue: 25 (6) Sequence Number: - Start / End Page: 421 - 423 Identifier: -