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  Influence of moderate hypercapnia on neural activity in monkey by simultaneous intracortical recordings and fMRI at 4.7T

Zappe, A.-C., Uludaq, K., Rainer, G., & Logothetis, N. (2005). Influence of moderate hypercapnia on neural activity in monkey by simultaneous intracortical recordings and fMRI at 4.7T. In 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005).

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Zappe, A-CC1, 2, Author           
Uludaq, K2, 3, Author           
Rainer, G1, 2, Author           
Logothetis, NK1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              

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 Abstract: Cerebral metabolic rate of oxygen (CMRO2) can be obtained with magnetic resonance imaging (MRI) by calibrating BOLD using hypercapnia. CO2 administration influences BOLD by increasing and eventually stabilizing blood flow and volume respectively. This leaves blood oxygenation as the predominating (if not the only) factor affecting the magnitude of BOLD. Obviously, the above assortment implies that CO2 increase acts exclusively as vasoactive agent, without affecting neuronal activity and hence oxygen metabolism. Amongst others, the latter assumption was strengthened by the results of Schmidt and Kety in the 50s. Most of the fMRI studies report coupling of cerebral blood flow (CBF) and oxygen metabolism (the ratio of fractional changes in CBF and CMRO2 is n = 2). In this study we investigated the dependence of neural activity on enhanced CO2 concentration by means of simultaneous intracortical recordings and BOLD imaging in the anesthetized macaque monkey.

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 Dates: 2005-11
 Publication Status: Issued
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 Identifiers: BibTex Citekey: 3841
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Title: 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005)
Place of Event: Washington, DC, USA
Start-/End Date: 2005-11-12 - 2005-11-16

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Title: 35th Annual Meeting of the Society for Neuroscience (Neuroscience 2005)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 10.11 Start / End Page: - Identifier: -