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  High-resolution 1H chemical shift imaging in the monkey visual cortex

Juchem, C., Logothetis, N., & Pfeuffer, J. (2005). High-resolution 1H chemical shift imaging in the monkey visual cortex. Magnetic Resonance in Medicine, 54(6), 1541-1546. doi:10.1002/mrm.20687.

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Juchem, C1, 2, Author           
Logothetis, NK1, 2, Author           
Pfeuffer, J1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Functionally distinct anatomic subdivisions of the brain can often be only a few millimeters in one or more dimensions. The study of metabolic differences in such structures by means of
localized in vivo MR spectroscopy is therefore challenging, if
not impossible. In fact, the spatial resolution of chemical shift
imaging (CSI) in humans is typically in the range of centimeters.
The aim of the present study was to optimize 1 H CSI in monkeys
and demonstrate the feasibility of high spatial resolutions up to
1.4 x 2 x 1.4 mm^3. The obtained spatial resolution permitted the
segregation of gray and white matter in the visual cortex based
on the concentration of different metabolites and neurotransmitters
like N-acetylaspartate, glutamate, and creatine. Concentration
ratios of white matter versus gray matter tissue as
well as between metabolites matched those reported in the
literature from healthy human brain, demonstrating the consistency
and reliability of the procedure.

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 Dates: 2005-10
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1002/mrm.20687
BibTex Citekey: 2891
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: 54 (6) Sequence Number: - Start / End Page: 1541 - 1546 Identifier: ISSN: 0740-3194
CoNE: https://pure.mpg.de/cone/journals/resource/954925538149