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  Structure of PTB Bound to RNA: Specific Binding and Implications for Splicing Regulation

Oberstrass, F., Auweter, S., Erat, M., Hargous, Y., Henning, A., Wenter, P., et al. (2005). Structure of PTB Bound to RNA: Specific Binding and Implications for Splicing Regulation. Science, 309(5743), 2054-2057. doi:10.1126/science.1114066.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D42F-F Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D793-3
Genre: Journal Article

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 Creators:
Oberstrass, FC, Author
Auweter, SD, Author
Erat, M, Author
Hargous, Y, Author
Henning, A1, Author              
Wenter, P, Author
Reymond, L, Author
Amir-Ahmady, B, Author
Pitsch, S, Author
Black, DL, Author
Allain, FH-T, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.

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 Dates: 2005-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1126/science.1114066
BibTex Citekey: OberstrassAEHHWRAPBA2005
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Title: Science
  Other : Science
Source Genre: Journal
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Publ. Info: Washington, D.C. : American Association for the Advancement of Science
Pages: - Volume / Issue: 309 (5743) Sequence Number: - Start / End Page: 2054 - 2057 Identifier: ISSN: 0036-8075
CoNE: https://pure.mpg.de/cone/journals/resource/991042748276600_1