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  Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging

Mamedov, I., Pfeuffer, J., Logotethis, N., & Mayer, H. (2005). Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging. Poster presented at 4th Annual Meeting of the Society for Molecular Imaging (SMI 2005), Köln, Germany.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D445-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-3C49-7
Genre: Poster

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 Creators:
Mamedov, I1, 2, Author              
Pfeuffer, J1, 2, Author              
Logotethis, NK1, 2, Author              
Mayer, HA, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Calcium plays an important role in regulating a great variety of neuronal processes, and many efforts are made to generate gadolinium complexes that can act as calcium-dependent MRI contrast agents. A series of gadolinium chelate complexes based on DO3A were developed, bearing phosphonate groups as an additional coordination sites, which is hypothesized to change relaxivity in magnetic resonance experiments dynamically with Ca2+ concentration. Different lengths of the phosphonate side chains are expected to lead to different binding constants of the phosphonate - gadolinium bonds. The latter property can be exploited for fine-tuning the sensitivity of the agent to calcium ion concentration.

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 Dates: 2005-07
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 4131
DOI: 10.1162/15353500200500210
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Title: 4th Annual Meeting of the Society for Molecular Imaging (SMI 2005)
Place of Event: Köln, Germany
Start-/End Date: 2005-09-07 - 2005-09-10

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Title: Molecular Imaging
Source Genre: Journal
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Pages: - Volume / Issue: 4 (3) Sequence Number: 224 Start / End Page: 276 Identifier: ISSN: 1536-0121