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  Phenotypic characterization of chondrosarcoma-derived cell lines

Schorle, C., Finger, F., Zien, A., Block, J., Gebhard, P., & Aigner, T. (2005). Phenotypic characterization of chondrosarcoma-derived cell lines. Cancer Letters, 226(2), 143-154. doi:10.1016/j.canlet.2004.11.022.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D49B-C Version Permalink: http://hdl.handle.net/21.11116/0000-0004-D79E-8
Genre: Journal Article

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 Creators:
Schorle, C, Author
Finger, F, Author
Zien, A1, 2, Author              
Block , J, Author
Gebhard, P, Author
Aigner, T, Author
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Gene expression profiling of three chondrosarcoma derived cell lines (AD, SM, 105KC) showed an increased proliferative activity and a reduced expression of chondrocytic-typical matrix products compared to primary chondrocytes. The incapability to maintain an adequate matrix synthesis as well as a notable proliferative activity at the same time is comparable to neoplastic chondrosarcoma cells in vivo which cease largely cartilage matrix formation as soon as their proliferative activity increases. Thus, the investigated cell lines are of limited value as substitute of primary chondrocytes but might have a much higher potential to investigate the behavior of neoplastic chondrocytes, i.e. chondrosarcoma biology.

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 Dates: 2005-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.canlet.2004.11.022
BibTex Citekey: 3514
 Degree: -

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Title: Cancer Letters
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 226 (2) Sequence Number: - Start / End Page: 143 - 154 Identifier: ISSN: 0304-3835
CoNE: https://pure.mpg.de/cone/journals/resource/954925511443_1