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  Functionalized azamacrocyclic compounds as Ca2+ sensitive contrast agents for MR imaging

Mamedov, I., Pfeuffer, J., Logothetis, N., & Mayer, H. (2005). Functionalized azamacrocyclic compounds as Ca2+ sensitive contrast agents for MR imaging. Poster presented at XXX. International Symposium on Macrocyclic Chemistry (ISMC 2005), Dresden, Germany.

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ISMC-2005-Mamedov.pdf (Any fulltext), 22KB
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 Creators:
Mamedov, I1, 2, Author              
Pfeuffer, J1, 2, Author              
Logothetis, NK1, 2, Author              
Mayer, HA, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: The ability to non-invasively observe changes in Ca2+ concentration is important for neuroscience. We have therefore developed a series of gadolinium chelate complexes based on DO3A (Scheme 1), which is hypothesized to change relaxivity in magnetic resonance experiments dynamically with Ca2+ concentration. Different lengths of the phosphonate side chains are expected to lead to different binding constants of the phosphonate - gadolinium bonds. The latter property can be exploited for fine-tuning the sensitivity of the agent to calcium ion concentration.

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 Dates: 2005-07
 Publication Status: Published online
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 Identifiers: BibTex Citekey: 3727
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Title: XXX. International Symposium on Macrocyclic Chemistry (ISMC 2005)
Place of Event: Dresden, Germany
Start-/End Date: 2005-07-17 - 2005-07-21

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