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  Lack of long-term cortical reorganization after macaque retinal lesions

Smirnakis, S., Brewer, A., Schmid, M., Tolias, A., Schüz, A., Augath, M., et al. (2005). Lack of long-term cortical reorganization after macaque retinal lesions. Nature, 435(7040), 300-307. doi:10.1038/nature03495.

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https://www.nature.com/articles/nature03495.pdf (Verlagsversion)
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Smirnakis, SM1, 2, Autor           
Brewer, AA, Autor
Schmid, MC1, 2, Autor           
Tolias, AS1, 2, Autor           
Schüz, A1, 2, Autor           
Augath, M1, 2, Autor           
Inhoffen , W, Autor
Wandell, BA, Autor
Logothetis, NK1, 2, Autor           
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Zusammenfassung: Several aspects of cortical organization are thought to remain plastic into adulthood, allowing cortical sensorimotor maps to be modified continuously by experience. This dynamic nature of cortical circuitry is important for learning, as well as for repair after injury to the nervous system. Electrophysiology studies suggest that adult macaque primary visual cortex (V1) undergoes large-scale reorganization within a few months after retinal lesioning, but this issue has not been conclusively settled. Here we applied the technique of functional magnetic resonance imaging (fMRI) to detect changes in the cortical topography of macaque area V1 after binocular retinal lesions. fMRI allows non-invasive, in vivo, long-term monitoring of cortical activity with a wide field of view, sampling signals from multiple neurons per unit cortical area. We show that, in contrast with previous studies, adult macaque V1 does not approach normal responsivity during 7.5 months of follow-up after retinal lesions, and its topography
does not change. Electrophysiology experiments corroborated the fMRI results. This indicates that adult macaque V1 has limited potential for reorganization in the months following retinal injury.

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 Datum: 2005-05
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.1038/nature03495
BibTex Citekey: 3325
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Titel: Nature
  Kurztitel : Nature
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: London : Nature Publishing Group
Seiten: - Band / Heft: 435 (7040) Artikelnummer: - Start- / Endseite: 300 - 307 Identifikator: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238