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  Lack of long-term cortical reorganization after macaque retinal lesions

Smirnakis, S., Brewer, A., Schmid, M., Tolias, A., Schüz, A., Augath, M., et al. (2005). Lack of long-term cortical reorganization after macaque retinal lesions. Nature, 435(7040), 300-307. doi:10.1038/nature03495.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D58D-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0004-95E0-6
Genre: Journal Article

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 Creators:
Smirnakis, SM1, 2, Author              
Brewer, AA, Author
Schmid, MC1, 2, Author              
Tolias, AS1, 2, Author              
Schüz, A1, 2, Author              
Augath, M1, 2, Author              
Inhoffen , W, Author
Wandell, BA, Author
Logothetis, NK1, 2, Author              
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Several aspects of cortical organization are thought to remain plastic into adulthood, allowing cortical sensorimotor maps to be modified continuously by experience. This dynamic nature of cortical circuitry is important for learning, as well as for repair after injury to the nervous system. Electrophysiology studies suggest that adult macaque primary visual cortex (V1) undergoes large-scale reorganization within a few months after retinal lesioning, but this issue has not been conclusively settled. Here we applied the technique of functional magnetic resonance imaging (fMRI) to detect changes in the cortical topography of macaque area V1 after binocular retinal lesions. fMRI allows non-invasive, in vivo, long-term monitoring of cortical activity with a wide field of view, sampling signals from multiple neurons per unit cortical area. We show that, in contrast with previous studies, adult macaque V1 does not approach normal responsivity during 7.5 months of follow-up after retinal lesions, and its topography does not change. Electrophysiology experiments corroborated the fMRI results. This indicates that adult macaque V1 has limited potential for reorganization in the months following retinal injury.

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 Dates: 2005-05
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1038/nature03495
BibTex Citekey: 3325
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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 435 (7040) Sequence Number: - Start / End Page: 300 - 307 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238