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  Multifunctional gadolinium-based ligand DO3A-EA as novel precursor for conjugation with bioorganic molecules to develop smart contrast agents for MR imaging

Mishra, A., Pfeuffer, J., Mishra, R., Logothetis, N., & Mishra, A. (2005). Multifunctional gadolinium-based ligand DO3A-EA as novel precursor for conjugation with bioorganic molecules to develop smart contrast agents for MR imaging. Poster presented at 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005), Miami Beach, FL, USA.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0013-D5A9-2 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-3E44-A
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 Creators:
Mishra, A1, 2, Author           
Pfeuffer, J1, 2, Author           
Mishra, R2, 3, Author           
Logothetis, NK1, 2, Author           
Mishra, AK1, 2, Author           
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              
3Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_2528700              

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 Abstract: Smart MR contrast agents are chelated paramagnetic molecules, whose relaxivity changes as a function of their chemical environment (e.g. changes in pH, calcium or neurotransmitter concentration). The multifunctional chelating agent DO3A-EA has been designed and synthesized as a valuable multifunctional precursor for smart MR contrast agents based on Gd-chelates. DO3A-EA was conjugated with diverse bioorganic molecules: 1) Gd-preloaded precursor Gd-DO3A-E-NCS with a highly reactive electrophile group for interaction with biological molecules or further synthesis. 2) Biotin-conjugated Gd-DO3A-E-Biotin for targeted imaging in an antibody-avidin system. 3) Fluorescence probe DO3A-E-FITC to track cell internalization and binding.

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 Dates: 2005-05
 Publication Status: Issued
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 Identifiers: BibTex Citekey: 3002
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Title: 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005)
Place of Event: Miami Beach, FL, USA
Start-/End Date: 2005-05-07 - 2005-05-13

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Title: 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2592 Start / End Page: - Identifier: -