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  On the Nature of the BOLD fMRI Contrast Mechanism

Logothetis, N., & Pfeuffer, J. (2004). On the Nature of the BOLD fMRI Contrast Mechanism. Magnetic Resonance Imaging, 22(10), 1517-1531.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D73B-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-509F-E
Genre: Conference Paper

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 Creators:
Logothetis, NK1, 2, Author              
Pfeuffer, J1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: First developed about fifteen years ago, functional magnetic resonance imaging (fMRI) has become the leading research tool for mapping brain activity. The technique works by detecting the levels of oxygen in the blood, point by point, throughout the brain. In other words it relies on a surrogate signal, resulting from changes in oxygenation, blood volume and flow, and does not directly measure neural activity. Although a relationship between changes in brain activity and blood flow has long been speculated, indirectly examined and suggested, and surely anticipated and expected, the neural basis of the fMRI signal was only recently demonstrated directly in experiments using combined imaging and intracortical recordings. In the present paper we discuss the results obtained via such combined experiments. We also discuss our current knowledge of the extracellularly measured signals, of the neural processes that they represent, and of the structural and functional neurovascular coupling, which links such processes with the hemodynamic changes that offer the surrogate signal we use to map brain activity. We conclude by considering applications of invasive MRI, including injections of paramagnetic tracers for the study of connectivity in the living animal, and simultaneous imaging and electrical microstimulation.

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 Dates: 2004-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.mri.2004.10.018
BibTex Citekey: 2893
 Degree: -

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Title: International School on Magnetic Resonance and Brain Function: 2nd Course Frontiers of Brain Functional MRI and Electrophysiological Methods 2004
Place of Event: Erice, Italy
Start-/End Date: 2004-05-23 - 2004-05-27

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Title: Magnetic Resonance Imaging
Source Genre: Journal
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Affiliations:
Publ. Info: New York : Elsevier
Pages: - Volume / Issue: 22 (10) Sequence Number: - Start / End Page: 1517 - 1531 Identifier: ISSN: 0730-725X
CoNE: https://pure.mpg.de/cone/journals/resource/954925533026