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  Effect of N-Acetyl Cysteine on Oxidative DNA Damage and the Frequency of DNA Deletions in Atm-Deficient Mice

Schiestl, R., Fischer, E., & Reliene, R. (2004). Effect of N-Acetyl Cysteine on Oxidative DNA Damage and the Frequency of DNA Deletions in Atm-Deficient Mice. Cancer research: an official organ of the American Association for Cancer Research, 64(15), 5148-5153. doi:10.1158/0008-5472.CAN-04-0442.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D801-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4917-0
Genre: Journal Article

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Schiestl, RH, Author
Fischer, E1, Author              
Reliene, R, Author
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1External Organizations, ou_persistent22              

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 Abstract: Ataxia telangiectasia (AT) is a hereditary human disorder resulting in a wide variety of clinical manifestations, including progressive neurodegeneration, immunodeficiency, and high incidence of lymphoid tumors. Cells from patients with AT show genetic instability, hypersensitivity to radiation, and a continuous state of oxidative stress. Oxidative stress and genetic instability, including DNA deletions, are involved in carcinogenesis. We examined the effect of dietary supplementation with the thiol-containing antioxidant N-acetyl-L-cysteine (NAC) on levels of oxidative DNA damage and the frequency of DNA deletions in Atm-deficient (AT-mutated) mice. We confirmed that Atm-deficient mice display an increased frequency of DNA deletions (Bishop et al., Cancer Res 2000;60:395). Furthermore, we found that Atm-deficient mice have significantly increased levels of 8-OH deoxyguanosine, an indication of oxidative DNA damage. Dietary supplementation with NAC significantly reduced 8-OH deoxyguanosine level and the frequ ency of DNA deletions in Atm-deficient mice. These levels were similar to the levels in wild-type mice. Our findings demonstrate that NAC counteracts genetic instability and suggest that genetic instability may be a consequence of oxidative stress in Atm-deficient mice.

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 Dates: 2004-08
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1158/0008-5472.CAN-04-0442
BibTex Citekey: 4939
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Title: Cancer research : an official organ of the American Association for Cancer Research
  Other : Cancer Res.
Source Genre: Journal
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Publ. Info: Baltimore, Md. : Waverly Press
Pages: - Volume / Issue: 64 (15) Sequence Number: - Start / End Page: 5148 - 5153 Identifier: ISSN: 0008-5472
CoNE: https://pure.mpg.de/cone/journals/resource/991042743115962