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  LIM genes parcellate the embryonic amygdala and regulate its development

Remedios, R., Subramanian, L., & Tole, S. (2004). LIM genes parcellate the embryonic amygdala and regulate its development. The Journal of Neuroscience, 24(31), 6986-6990. doi:10.1523/JNEUROSCI.0001-04.2004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D811-D Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4BBA-6
Genre: Journal Article

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 Creators:
Remedios, R1, Author              
Subramanian, L, Author
Tole, S, Author
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1External Organizations, ou_persistent22              

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 Abstract: The mechanisms that regulate the development of the amygdaloid complex are as yet poorly understood. Here, we show that in the absence of the LIM-homeodomain (LIM-HD) gene Lhx2, a particular amygdaloid nucleus, the nucleus of the lateral olfactory tract (nLOT), is selectively disrupted. LIM family members are well suited for multiple roles in the development of complex structures because they participate in regulatory interactions that permit a diversity of function. To investigate the possible role for other LIM-HD genes as well as LIM-only (Lmo) genes in the developing amygdala, we examined their expression in the embryo. We show that amygdaloid nuclei upregulate distinct patterns of LIM gene expression from embryonic stages. This supports the hypothesis that LIM genes may participate in the mechanisms that control the development of the amygdala. The disruption of the nLOT in the Lhx2 mutant is the first evidence of a role for LIM-HD genes in the development of the amygdaloid complex. The combinatorial expression patterns of LIM genes suggest a comprehensive mechanism for patterning this structure.

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 Dates: 2004-08
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1523/JNEUROSCI.0001-04.2004
BibTex Citekey: 4663
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Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
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Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 24 (31) Sequence Number: - Start / End Page: 6986 - 6990 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1