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  Perfusion-based high-resolution fMRI in the primate brain using a novel vertical large-bore 7 Tesla setup

Pfeuffer, J., Steudel, T., Merkle, H., & Logothetis, N. (2004). Perfusion-based high-resolution fMRI in the primate brain using a novel vertical large-bore 7 Tesla setup. Poster presented at 10th Annual Meeting of the Organization for Human Brain Mapping (HBM 2004), Budapest, Hungary.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-D91B-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-6410-8
Genre: Poster

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 Creators:
Pfeuffer, J1, 2, Author              
Steudel, T1, 2, 3, Author              
Merkle, H, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Dept. Empirical Inference, Max Planck Institute for Intelligent System, Max Planck Society, ou_1497647              

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 Abstract: Functional MR imaging in monkeys promises to build a bridge between brain research in humans and the large body of systems neuroscience work in animals. Simultaneous fMRI and electrophysiology was recently used in the anesthetized monkey to elucidate the neural activity underlying the fMRI BOLD signal [1]. Perfusion-based MRI measures cerebral blood flow (CBF) at the capillary level and can be used for functional studies based on the tight spatial coupling between brain activity and blood flow. From CBF changes and interleaved-acquired BOLD data, changes in oxygen consumption can be calculated. Obtaining functional CBF maps with high spatial resolution is a major challenge, because the CBF signal is intrinsically low and the signal-to-noise ratio is critical. In this study, high-resolution CBF maps were obtained with voxel sizes as small as 0.5 x 0.5 x 3 mm3 in the Macaca mulatta for the first time. High sensitivity was made possible by signal-to-noise gains at the high magnetic field of 7 Tesla and by using a customized RF combination coil design. In first experiments, CBF maps and functional CBF data were acquired and compared with functional BOLD data in the primary visual cortex. For CBF, large contrast-to-noise gains were obtained at high spatial resolution similar as previously reported in humans [2]. These first results demonstrate that the sensitivity gains at high field can be used to study CBF changes in primate brain with spatial dimensions well below the cortical thickness. This is significant for the understanding of localized brain function and the physiological basis of functional neuroimaging.

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 Dates: 2004-06
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1016/S1053-8119(05)70020-3
BibTex Citekey: 2530
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Title: 10th Annual Meeting of the Organization for Human Brain Mapping (HBM 2004)
Place of Event: Budapest, Hungary
Start-/End Date: 2004-06-13 - 2004-06-17

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 22 (Supplement 1) Sequence Number: TH 317 Start / End Page: e2424 - e2426 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166