English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Constant-Infusion H215O PET and Acetazolamide Challenge in the Assessment of Cerebral Perfusion Status

Weber, B., Westera, G., Treyer, V., Burger, C., Kahn, N., & Buck, A. (2004). Constant-Infusion H215O PET and Acetazolamide Challenge in the Assessment of Cerebral Perfusion Status. Journal of Nuclear Medicine, (45), 1344-1350.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DA59-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-5021-B
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Weber, B1, Author              
Westera , G, Author
Treyer, V, Author
Burger , C, Author
Kahn, N, Author
Buck, A, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Assessing the baseline perfusion and perfusion reserve after acetazolamide (ACZ) challenge is a common method for the evaluation of patients with cerebrovascular disease. Most previous studies using H215O PET applied the bolus injection technique. There is considerable discrepancy regarding the optimal time point of imaging after ACZ injection. The purpose of this study was to continuously monitor cerebral blood flow (CBF) after ACZ using constant-infusion H215O PET. Methods: Four patients with stenoses of an internal carotid artery and 6 with moyamoya disease were studied. H215O was continuously infused, and data were recorded in 1-min frames. After equilibration of H215O, 5 min of baseline data were acquired, and then 1 g of ACZ was administered intravenously and data collection continued for 10–22 min. Arterial blood was continuously drawn for absolute quantification of CBF. Results: The arterial 15O concentration remained generally stable during scanning, and the cerebellar blood flow fluctuations of the 5 baseline scans were small. The scan-to-scan difference was 6% (difference of 2 successive scans/mean). In the nonpathologic areas, the increase in CBF started 1–2 min after administration of ACZ. The largest fraction of the increase occurred from 0 to 10 min. The ratio of CBF in pathologic areas to CBF in cerebellum showed an initial decrease that stabilized after 5 min. Conclusion: A continuous-infusion protocol is a viable alternative to single bolus injections for the assessment of cerebral perfusion status. Such a protocol is advantageous when the time course of CBF after an intervention is not known. With continuous monitoring, the optimal time point for evaluation of a certain parameter can be chosen post hoc. Furthermore, the time course of CBF itself may allow the definition of new parameters for evaluating perfusion status in cerebrovascular patients, both for assessment before a revascularization procedure and for follow-up. A limitation of the present study is the relatively small number of patients with each type of cerebrovascular disease and the lack of healthy subjects.

Details

show
hide
Language(s):
 Dates: 2004-08
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: BibTex Citekey: 2647
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Nuclear Medicine
  Other : J. Nucl. Med.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Society of Nuclear Medicine
Pages: - Volume / Issue: (45) Sequence Number: - Start / End Page: 1344 - 1350 Identifier: ISSN: 0161-5505
CoNE: https://pure.mpg.de/cone/journals/resource/991042725914954