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  Influence of ceftriaxone treatment on FDG uptake: An in vivo 18F-fluorodeoxyglucose study in soft tissue infections in rats

Wyss, M., Honer, M., Spath, N., Gottschalk, J., Ametamey, S., Weber, B., et al. (2004). Influence of ceftriaxone treatment on FDG uptake: An in vivo 18F-fluorodeoxyglucose study in soft tissue infections in rats. Nuclear Medicine and Biology, 31(7), 875-882. doi:10.1016/j.nucmedbio.2004.06.001.

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Wyss, M, Author
Honer, M, Author
Spath, N, Author
Gottschalk, J, Author
Ametamey, SM, Author
Weber, B1, Author              
von Schulthess, GK, Author
Buck, A, Author
Kaim, AH, Author
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1External Organizations, ou_persistent22              

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 Abstract: Our aim was to determine the influence of antibiotic treatment using ceftriaxone on [18F]-fluorodeoxyglucose (FDG) uptake in experimental soft tissue infections. PET scans were performed in two groups (treated n=4; non-treated n=4) at days 3, 5, and 6 after inoculation of the infection. Additional autoradiography was performed in four animals at day 7 and in three animals at day 11. The difference of FDG uptake on day 5 (after three days of antibiotic treatment) between both groups proved to be significant (df=6; T=2.52; p=0.045). FDG uptake determined at the other days did not reveal significant difference between the two groups. It seems to be possible that the effect of antibiotic treatment on FDG uptake is less evident than reported for therapy monitoring of cancer treatment. The change of FDG uptake over time in treated and untreated infections is complex and further in vivo experiments have to be initiated to investigate the potential value of clinical FDG PET in therapy monitoring of infection.

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 Dates: 2004-10
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: BibTex Citekey: 3059
DOI: 10.1016/j.nucmedbio.2004.06.001
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Title: Nuclear Medicine and Biology
  Abbreviation : Nucl. Med. Biol.
Source Genre: Journal
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Publ. Info: New York, NY [u.a.] : Elsevier
Pages: - Volume / Issue: 31 (7) Sequence Number: - Start / End Page: 875 - 882 Identifier: ISSN: 1872-9614
CoNE: https://pure.mpg.de/cone/journals/resource/1872-9614