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  Optical Imaging of the Spatiotemporal Dynamics of Cerebral Blood Flow and Oxidative Metabolism in the Rat Barrel Cortex

Weber, B., Burger, C., Wyss, M., von Schulthess, G., Scheffold, F., & Buck, A. (2004). Optical Imaging of the Spatiotemporal Dynamics of Cerebral Blood Flow and Oxidative Metabolism in the Rat Barrel Cortex. European Journal of Neuroscience: European Neuroscience Association, 20(10), 2664-2670. doi:10.1111/j.1460-9568.2004.03735.x.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-F3D9-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-504C-C
Genre: Journal Article

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Weber, B1, Author              
Burger, C, Author
Wyss, M, Author
von Schulthess, GK, Author
Scheffold, F, Author
Buck, A, Author
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1External Organizations, ou_persistent22              

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 Abstract: Oxidative metabolism and cerebral blood flow (CBF) are two of the most important measures in neuroimaging. However, results from concurrent imaging of the two with high spatial and temporal resolution have never been published. We used flavoprotein autofluorescence (AF) and laser speckle imaging (LSI) in the anaesthetized rat to map oxidative metabolism and CBF in response to single vibrissa stimulation. Autofluorescence responses reflecting oxidative metabolism demonstrated a fast increase with a delay of 0.1 s. The sign‐reversed speckle contrast reflecting CBF started to rise with a delay of 0.6 s and reached its maximum 1.4 s after the stimulation offset. The fractional signal changes were 2.0% in AF and 9.7% in LSI. Pixelwise modelling revealed that CBF maps spread over an area up to 2.5‐times larger than metabolic maps. The results provide evidence that the increase in cerebral oxidative metabolism in response to sensory stimulation is considerably faster and more localized than the CBF response. This suggests that future developments in functional imaging concentrating on the metabolic response promise an increased spatial resolution.

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 Dates: 2004-11
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: BibTex Citekey: 2881
DOI: 10.1111/j.1460-9568.2004.03735.x
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Title: European Journal of Neuroscience : European Neuroscience Association
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 20 (10) Sequence Number: - Start / End Page: 2664 - 2670 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988