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  Clustering Protein Sequence and Structure Space with Infinite Gaussian Mixture Models

Dubey, A., Hwang, S., Rangel, C., Rasmussen, C., Ghahramani, Z., & Wild, D. (2004). Clustering Protein Sequence and Structure Space with Infinite Gaussian Mixture Models. In Pacific Symposium on Biocomputing (PSB 2004) (pp. 399-410). Singapore: World Scientific Publishing.

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 Creators:
Dubey, A, Author
Hwang, S, Author
Rangel, C, Author
Rasmussen, CE1, 2, Author              
Ghahramani, Z, Author
Wild, DL, Author
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: We describe a novel approach to the problem of automatically clustering protein sequences and discovering protein families, subfamilies etc., based on the thoery of infinite Gaussian mixture models. This method allows the data itself to dictate how many mixture components are required to model it, and provides a measure of the probability that two proteins belong to the same cluster. We illustrate our methods with application to three data sets: globin sequences, globin sequences with known tree-dimensional structures and G-pretein coupled receptor sequences. The consistency of the clusters indicate that that our methods is producing biologically meaningful results, which provide a very good indication of the underlying families and subfamilies. With the inclusion of secondary structure and residue solvent accessibility information, we obtain a classification of sequences of known structure which reflects and extends their SCOP classifications. A supplementary web site containing larger versions of the figures is available at http://public.kgi.edu/~wild/PSB04

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 Dates: 2004-01
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 2373
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Title: Pacific Symposium on Biocomputing (PSB 2004)
Place of Event: Waimea, HI, USA
Start-/End Date: 2004-01-06 - 2004-01-10

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Title: Pacific Symposium on Biocomputing (PSB 2004)
Source Genre: Proceedings
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Publ. Info: Singapore : World Scientific Publishing
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 399 - 410 Identifier: -