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  Simultaneous electrical microstimulation and fMRI in the macaque

Tolias, A., Augath, M., Pauls, J., Oeltermann, A., Tehovnik, E., Schiller, P., et al. (2003). Simultaneous electrical microstimulation and fMRI in the macaque. Poster presented at 33rd Annual Meeting of the Society for Neuroscience (Neuroscience 2003), New Orleans, LA, USA.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DB03-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-76DC-F
Genre: Poster

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Tolias, AS1, 2, Author              
Augath, M1, 2, Author              
Pauls, J1, 2, Author              
Oeltermann, A1, 2, Author              
Tehovnik , EJ, Author
Schiller, PH, Author
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Electrical microstimulation has been used extensively to study both neuronal connectivity and the behavioral effects of focal neural excitation. Yet most behaviors involve concurrent activation of several structures that are directly or indirectly interconnected with the stimulated site. Microstimulation performed simultaneously with fMRI offers a unique opportunity to investigate the network of structures eliciting certain behaviors. Recently, simultaneous recording of neural activity and BOLD responses in the monkey has been developed to study the correlation between the fMRI signals and electrical activity in the brain (Logothetis et al., 2001). This work has also enabled us to carry out simultaneous electrical microstimulation and fMRI. The specific goal of the current study is to determine the electrical parameters which elicit activity in the brain similar to that generated by focal visual stimulation. We compared visual stimulation with constant-current charge-balanced biphasic electrical pulses delivered via monopolar microelectrodes placed in area V1. We find that under certain microstimulation parameters we obtain focal activity around the electrode tip in area V1 as well the corresponding retinotopic location in area V2, V3, and MT. Ongoing research examines the activity patterns elicited by stimulating at different cortical layers of V1. This study paves the way to incorporate the much needed anatomical information in the analysis of the electrical signals obtained in trained, awake animals.

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 Dates: 2003-11
 Publication Status: Published online
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 Identifiers: BibTex Citekey: 4502
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Title: 33rd Annual Meeting of the Society for Neuroscience (Neuroscience 2003)
Place of Event: New Orleans, LA, USA
Start-/End Date: 2003-11-08 - 2003-11-12

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Title: 33rd Annual Meeting of the Society for Neuroscience (Neuroscience 2003)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 69.20 Start / End Page: - Identifier: -