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  Microarrays: How Many Do You Need?

Zien, A., Fluck, J., Zimmer, R., & Lengauer, T. (2003). Microarrays: How Many Do You Need? Journal of Computational Biology, 10(3-4), 653-667. doi:10.1089/10665270360688246.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DD70-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-6B2D-2
Genre: Journal Article

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 Creators:
Zien, A1, 2, Author              
Fluck, J, Author
Zimmer, R, Author
Lengauer, T, Author
Affiliations:
1Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497795              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: We estimate the number of microarrays that is required in order to gain reliable results from a common type of study: the pairwise comparison of different classes of samples. We show that current knowledge allows for the construction of models that look realistic with respect to searches for individual differentially expressed genes and derive prototypical parameters from real data sets. Such models allow investigation of the dependence of the required number of samples on the relevant parameters: the biological variability of the samples within each class, the fold changes in expression that are desired to be detected, the detection sensitivity of the microarrays, and the acceptable error rates of the results. We supply experimentalists with general conclusions as well as a freely accessible Java applet at www.scai.fhg.de/special/bio/howmanyarrays/ for fine tuning simulations to their particular settings.

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 Dates: 2003-06
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: 2145
DOI: 10.1089/10665270360688246
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Title: Journal of Computational Biology
Source Genre: Journal
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Publ. Info: New York, NY : Mary Ann Liebert
Pages: - Volume / Issue: 10 (3-4) Sequence Number: - Start / End Page: 653 - 667 Identifier: ISSN: 1066-5277
CoNE: https://pure.mpg.de/cone/journals/resource/954925275499