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  Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain

Shmuel, A., Yacoub E, Pfeuffer, J., Ugurbil, K., & Al, E. (2002). Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron, 36(6), 1195-1210. Retrieved from http://www.neuron.org/cgi/content/abstract/36/6/1195.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DE30-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DE31-8
Genre: Journal Article

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Shmuel, A1, Author              
Yacoub E, Pfeuffer, J1, Author              
Ugurbil, K, Author
Al, E, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              

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 Abstract: Most fMRI studies are based on the detection of a positive BOLD response (PBR). Here, we demonstrate and characterize a robust sustained negative BOLD response (NBR) in the human occipital cortex, triggered by stimulating part of the visual field. The NBR was spatially adjacent to but segregated from the PBR. It depended on the stimulus and thus on the pattern of neuronal activity. The time courses of the NBR and PBR were similar, and their amplitudes covaried both with increasing stimulus duration and increasing stimulus contrast. The NBR was associated with reductions in blood flow and with decreases in oxygen consumption. Our findings support the contribution to the NBR of (1) a significant component of reduction in neuronal activity and (2) possibly a component of hemodynamic changes independent of the local changes in neuronal activity.

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 Dates: 2002-12
 Publication Status: Published in print
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 Identifiers: URI: http://www.neuron.org/cgi/content/abstract/36/6/1195
BibTex Citekey: 2217
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 36 (6) Sequence Number: - Start / End Page: 1195 - 1210 Identifier: -