English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Sustained negative BOLD response in the monkey brain

Shmuel, A., Augath, M., Oeltermann, A., & Logothetis, N. (2002). Sustained negative BOLD response in the monkey brain. Poster presented at 32nd Annual Meeting of the Society for Neuroscience (Neuroscience 2002), Orlando, FL, USA.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DEC5-D Version Permalink: http://hdl.handle.net/21.11116/0000-0005-97A7-4
Genre: Poster

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Shmuel, A1, 2, Author              
Augath, M1, 2, Author              
Oeltermann, A1, 2, Author              
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

Content

show
hide
Free keywords: -
 Abstract: n a previous fMRI study (Shmuel et al., HBM 2001), a robust sustained negative BOLD response (NBR) and blood flow response was detected in the human occipital cortex. Here we report on a sustained (different from the initial dip) NBR in areas V1, V2, and V3 of the macaque. Anesthetized monkeys were presented in 4 cycles with a rotating polar checker pattern (48 s) followed by a blank gray image (48 s). Fifteen axial slices were imaged (GE-EPI, 4.7 T, 0.750.752 mm, TR=.75 s, 6 s/volume). In response to stimulation at 0-10 eccentricity, a positive BOLD response (PBR) and NBR were observed within the central and peripheral visual representation, respectively. The NBR was found preferentially in gray matter and was spatially reproducible across subjects. The time course of the NBR and PBR (mean amplitude ratio 0.5) were similar, suggesting similar mechanisms. Initial results from simultaneous fMRI and electrophysiology demonstrated NBR in 3 regions where no robust changes in electrical activity occurred. We are currently pursuing additional fMRI-electrophysiology experiments. Discussion 1) Robust NBR exists in the monkey brain. 2) Since the activity in the periphery is not expected to increase, the NBR here is the result of a decrease in blood flow rather than increase in oxygen consumption.

Details

show
hide
Language(s):
 Dates: 2002-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: 1586
 Degree: -

Event

show
hide
Title: 32nd Annual Meeting of the Society for Neuroscience (Neuroscience 2002)
Place of Event: Orlando, FL, USA
Start-/End Date: 2002-11-02 - 2002-11-07

Legal Case

show

Project information

show

Source 1

show
hide
Title: 32nd Annual Meeting of the Society for Neuroscience (Neuroscience 2002)
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: 759.6 Start / End Page: - Identifier: -