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  Zoomed Functional Imaging in the Human Brain at 7 Tesla with Simultaneous High Spatial and High Temporal Resolution

Pfeuffer, J., de Moortele, P.-E., Yacoub, E., Shmuel, A., Adriany, g., Andersen p, P., et al. (2002). Zoomed Functional Imaging in the Human Brain at 7 Tesla with Simultaneous High Spatial and High Temporal Resolution. NeuroImage, 17(1), 272-286. doi:10.1006/nimg.2002.1103.

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Pfeuffer, J1, Autor           
de Moortele, P-EV, Autor
Yacoub, E, Autor
Shmuel, A1, Autor           
Adriany , g, Autor
Andersen p, P, Autor
Merkle, H1, Autor           
Garwood, M, Autor
Ugurbil, K, Autor
Hu, X, Autor
Affiliations:
1External Organizations, ou_persistent22              

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 Zusammenfassung: Functional neuroimaging in the human brain using non-invasive magnetic resonance methods has the potential of providing highly resolved maps of neuronal activation. Decreasing the voxel size and obtaining simultaneously high temporal resolution is a major challenge and is mainly limited by sensitivity. Here, signal-to-noise gains at high magnetic fields (7 Tesla) and an optimized surface coil setup are combined with a novel approach for zoomed functional imaging in the visual cortex. For echo-planar imaging, the acquisition time and segmentation was shortened fourfold by using a reduced field-of-view. An adiabatic outer-volume suppression method, BISTRO, was used to obliterate signal outside the area-of-interest achieving effective suppression even for inhomogeneous B1-fields. A single-shot acquisition was performed at sub-millimeter resolution in the human brain, while simultaneously maintaining a high temporal resolution of 125 ms. Functional studies with and without field-of-view reduction were performed. Activation and percent change maps were compared with respect to spatial extent, t-values and percent changes of the BOLD contrast. The detection of functional activation was found to be equal within the inter-series variability for the two acquisition schemes. Thus, single-trial BOLD responses were detected for the first time robustly at a 500 x 500 µm2 in plane and 250 ms temporal resolution, significantly expanding the possibilities of event-related functional imaging in the human brain. The magnetization transfer effect induced by the outer-volume suppression pulses was investigated and found to be increased during neuronal activity.

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 Datum: 2002-09
 Publikationsstatus: Erschienen
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 Identifikatoren: DOI: 10.1006/nimg.2002.1103
BibTex Citekey: 1221
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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 17 (1) Artikelnummer: - Start- / Endseite: 272 - 286 Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166