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  Ultra High-Resolution fMRI in Monkeys with Implanted RF Coils

Logothetis, N., Merkle, H., Augath, M., Trinath, T., & Ugurbil, K. (2002). Ultra High-Resolution fMRI in Monkeys with Implanted RF Coils. Neuron, 35(2), 227-242. doi:10.1016/S0896-6273(02)00775-4.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DF86-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DF87-2
Genre: Journal Article

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 Creators:
Logothetis, NK1, Author              
Merkle, H2, Author              
Augath, MA1, Author              
Trinath, T1, Author              
Ugurbil, K, Author
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Spatiotemporally resolved functional MRI (fMRI) in animals can reveal how wide-spread neural networks are organized and accompanying electrophysiological recordings can show how small neural assemblies contribute to this organization. Here we present a novel technique that yields high-resolution structural and functional images of the monkey brain with small, tissue-compatible, intraosteally implantable radiofrequency coils. Voxel sizes as small as 0.0113 μl with high signal-to-noise and contrast-to-noise ratios were obtained, revealing both structural and functional cortical architecture in great detail. Up to a certain point, contrast sensitivity increased with decreasing voxel size, probably because of the decreased partial volume effects. Spatial specificity was demonstrated by the lamina-specific activation in experiments comparing responses to moving and flickering stimuli. The implications of this technique for combined fMRI/electrophysiology experiments and its limitations in terms of spatial coverage are discussed.

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 Dates: 2002-07
 Publication Status: Published in print
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Title: Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 35 (2) Sequence Number: - Start / End Page: 227 - 242 Identifier: -