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  Magnetic Resonance Imaging of Neuronal Connections in the Macaque Monkey

Saleem, K., Pauls, J., Augath, M., Trinath, T., Prause, B., Hashikawa, T., et al. (2002). Magnetic Resonance Imaging of Neuronal Connections in the Macaque Monkey. Neuron, 34(5), 685-700. doi:10.1016/S0896-6273(02)00718-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DFB6-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-8414-F
Genre: Journal Article

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 Creators:
Saleem, KS, Author
Pauls, J1, 2, Author              
Augath, MA1, 2, Author              
Trinath, T1, 2, Author              
Prause, BA1, 2, Author              
Hashikawa, T, Author
Logothetis, NK1, 2, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Recently, an MRI-detectable, neuronal tract-tracing method in living animals was introduced that exploits the anterograde transport of manganese (Mn2+). We present the results of experiments simultaneously tracing manganese chloride and wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) to evaluate the specificity of the former by tracing the neuronalconnections of the basal ganglia of the monkey. Mn2+ and WGA-HRP yielded remarkably similar and highly specific projection patterns. By showing the sequential transport of Mn2+ from striatum to pallidum-substantia nigra and then to thalamus, we demonstrated MRI visualization of transport across at least one synapse in the CNS of the primate. Transsynaptic tract tracing in living primates will allow chronic studies of development and plasticity and provide valuable anatomical information for fMRI and electrophysiological experiments in primates.

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 Dates: 2002-05
 Publication Status: Published in print
 Pages: -
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 Rev. Method: -
 Identifiers: DOI: 10.1016/S0896-6273(02)00718-3
BibTex Citekey: 926
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 34 (5) Sequence Number: - Start / End Page: 685 - 700 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565