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  Sustained Negative BOLD and Blood Flow Response and its Coupling to the Positive Response in the Human Brain

Shmuel, A., Yacoub, E., Pfeuffer, J., Van de Moortele, P.-F., Adriany, G., Ugurbil, K., et al. (2002). Sustained Negative BOLD and Blood Flow Response and its Coupling to the Positive Response in the Human Brain. In 10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002).

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-DFE6-A Version Permalink: http://hdl.handle.net/21.11116/0000-0005-A54A-E
Genre: Meeting Abstract

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ISMRM-2002-Shmuel.pdf (Any fulltext), 284KB
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ISMRM-2002-Shmuel.pdf
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https://cds.ismrm.org/ismrm-2002/START.pdf (Table of contents)
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 Creators:
Shmuel, A1, Author              
Yacoub, E, Author
Pfeuffer, J1, Author              
Van de Moortele , P-F, Author
Adriany, G, Author
Ugurbil, K, Author
Hu, X, Author
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1External Organizations, ou_persistent22              

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 Abstract: Most fMRI studies are based on the detection of a positive BOLD response (PBR). A few previous human studies indicated the existence of negatively responding voxels in brain regions remote from the focus of PBR (1, 2, and others). Recent studies in the anesthetized cat (3) and monkey (4) have demonstrated adjacent PBR and negative BOLD response (NBR). In this study we demonstrate sustained (different from the "initial dip") negative BOLD response (NBR) that occurs concurrently with and is coupled to the positive response, via a mechanism that involves a reduction in blood flow (CBF) to the less demanding regions in the human brain.

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 Dates: 2002-05
 Publication Status: Published in print
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 Identifiers: BibTex Citekey: 1230
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Title: 10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002)
Place of Event: Honolulu, HI, USA
Start-/End Date: 2002-05-18 - 2002-05-24

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Title: 10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 642 Start / End Page: - Identifier: -