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  Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use

Haselhorst, R., Dürsteler-MacFarland, K., Scheffler, K., Ladewig, D., Müller-Spahn, F., Stohler, R., et al. (2002). Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use. Neurology, 58(2), 305-307. doi:10.1212/WNL.58.2.305.

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https://n.neurology.org/content/58/2/305 (Publisher version)
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Haselhorst, R, Author
Dürsteler-MacFarland, KM, Author
Scheffler, K1, Author              
Ladewig, D, Author
Müller-Spahn, F, Author
Stohler, R, Author
Seelig, J, Author
Seifritz, E, Author
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1External Organizations, ou_persistent22              

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 Abstract: To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by 1H-MRS. Compared with controls, NAA levels in patients were reduced by 7 in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.

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 Dates: 2002-01
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1212/WNL.58.2.305
BibTex Citekey: HaselhorstDSLMSSS2002
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Title: Neurology
Source Genre: Journal
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Publ. Info: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Pages: - Volume / Issue: 58 (2) Sequence Number: - Start / End Page: 305 - 307 Identifier: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073