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  White matter glucose metabolism during intracortical electrostimulation: a quantitative [(18)F]Fluorodeoxyglucose autoradiography study in the rat

Weber, B., Fouad, K., Burger, C., & Buck, A. (2002). White matter glucose metabolism during intracortical electrostimulation: a quantitative [(18)F]Fluorodeoxyglucose autoradiography study in the rat. NeuroImage, 16(4), 993-998. doi:10.1006/nimg.2002.1104.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0013-E0DF-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-8931-9
Genre: Journal Article

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Weber, B1, Author              
Fouad , K, Author
Burger, C, Author
Buck, A, Author
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1External Organizations, ou_persistent22              

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 Abstract: [(18)F]Fluorodeoxyglucose (FDG) autoradiography was used to analyze the effects of intracortical electrostimulation on local cerebral metabolic rate for glucose (LCMRglu). The hindleg area in rat brains was electrically stimulated with different frequencies (0, 0.1, 0.25, 0.5, 0.75, 1 stimulus trains per second, two animals per condition). The major result was a strong positive correlation between stimulation frequency and LCMRglu in the callosal fibers originating in the stimulated cortical area. At the highest stimulation frequency callosal LCMRglu was 50.01 micromol/min/100 g compared to 27.87 micromol/min/100 g at baseline. LCMRglu in gray and white matter control areas was stable across conditions. Direct injection of FDG in the stimulated cortex failed to produce increased callosal uptake, excluding the possibility that FDG uptake in the corpus callosum is related to axonal diffusion. Although several previous autoradiographic studies have demonstrated alterations in LCMRglu in white matter, correlations between neural activity and LCMRglu have never been explicitly addressed. Changes in white matter metabolism most likely reflect changes of electrical fiber activity and thus the presented results bear important implications for brain imaging studies.

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 Dates: 2002-08
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: BibTex Citekey: 2653
DOI: 10.1006/nimg.2002.1104
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 16 (4) Sequence Number: - Start / End Page: 993 - 998 Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166